CORRELATION ENTRE LE STATUT DE VITAMINE D ET LE TITRE D’ANTICORPS ANTITHYROIDIENS DANS LA THYROIDITE D’HASHIMOTO CHEZ LES PATIENTS DE LA WILAYA DE TLEMCEN

Abstract

Summary Introduction: Hashimoto's thyroiditis is characterised by the presence of antithyroid antibodies and lymphocyte infiltration of the thyroid gland. Its etiology results from an interaction of environmental factors and genetic traits of susceptibility. One of the most recent factors involved in autoimmunity is Vit D. The main objective of our study is to investigate the relationship between the status of Vit D and antithyroid antibody levels in patients with thyroiditis Hashimoto newly diagnosed from the Wilaya of Tlemcen. Materials and Methods: Observational, analytical, case-control study of 310 subjects, including a group of cases (n = 155) and a control group (n = 155), matched by sex, age, age and sex. IMC and the sampling season. All the subjects benefited from a biological assay (TSH, FT4, anti-TPO, anti-hTg, 25 (OH) D, PTH) and a biochemical assay (calcemia, phosphoremia, albuminemia, PAL). Results: Vit D deficiency is 98% in our population. The risk factors most significantly associated with low 25 (OH) D levels are sex, lack of sun exposure, season and skin color. Comparison of the 25 (OH) D (ng / mL) means between the two groups found a more pronounced deficit in the patients. The correlation between the status of 25 (OH) D and anti-TPO is inverse and significant (r = - 0.185, p = 0.02). Moreover, there is no correlation between 25 (OH) D and anti-hTg, or between the deficit in Vit D and the depth of biological hypothyroidism. Conclusion: There is a statistical relationship between 25 (OH) D and anti-TPO in the patient group, however the exact involvement of 25 (OH) D in the immunopathogenesis of Hashimoto's thyroiditis remains to be substantiated.