ÉVALUATION DU DOSAGE DE LA CALCITONINE (CT) DANS LE LIQUIDE DE PONCTION NODULAIRE ET/OU GANGLIONNAIRE DANS LE DIAGNOSTIC DU CANCER MEDULLAIRE DE LA THYROIDE (CMT) ET DE SES MÉTASTASES GANGLIONNAIRES

Abstract

Medullary thyroid carcinoma (MTC) is a rare but relatively serious disease, whose prognosis depends on the stage of the tumor and the quality of the initial surgical treatment. The determination of the plasma calcitonin, cervical ultrasound, and fine needle aspiration biopsy are first line examinations, nevertheless they do not always make it possible to make a certain diagnosis in preoperative, moreover they do not define the MTC nodule in a multi nodular goiter and the metastatic lymph nodes. In this study, fine needle aspiration (FNA) and CT FNA were performed in 45 lesions. By comparing the results to histology, the sensitivity of the FNA for the diagnosis is estimated at 53.12% and the specificity at 92.30% while the sensitivity of the CT FNA is 96.87% and the specificity is 100% and this for a cut off >22.99pg/ml. These results suggest that CT FNA, a simple, accessible and inexpensive exam, represents an interesting diagnostic approach that provides an additional argument for the positive and topographic diagnosis of MTC. Keywords: Medullary Thyroid Carcinoma, Calcitonin, Fine needle aspiration (FNA), CT FNA.